Open AccessExercise‐Induced Ventricular Arrhythmias and Cardiovascular Death
Author(s) -
Beckerman James,
Mathur Anima,
Stahr Stephen,
Myers Jonathan,
Chun Sung,
Froelicher Victor
Publication year - 2005
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/j.1542-474x.2005.00599.x
Subject(s) - medicine , cardiology , hazard ratio , veterans affairs , proportional hazards model , population , disease , st depression , ischemia , myocardial infarction , st segment , confidence interval , environmental health
Background: Exercise‐induced ventricular arrhythmias (EIVA) are frequently observed during exercise testing. However, the clinical guidelines do not specify their significance and so we examined this issue in our population. Methods: A retrospective analysis of prospectively collected data was performed on 5754 consecutive male veterans referred for exercise testing at two university‐affiliated Veterans Affairs Medical Centers. Exercise test responses were recorded and cardiovascular mortality was assessed after a mean follow‐up of 6 ± 4 years. EIVA were defined as frequent premature ventricular complexes (PVCs) constituting more than 10% of all ventricular depolarizations during any 30‐second ECG recording, or a run of three or more consecutive PVCs during the exercise test or recovery. Results: EIVA occurred in 426 patients (7.4%). There were 550 (10.6%) cardiovascular deaths during follow‐up. Seventy two (17%) patients with EIVA died of cardiovascular causes, whereas 478 (9.0%) of patients without EIVA died of cardiovascular causes (P < 0.001). Patients with EIVA had a higher prevalence of cardiovascular disease, resting PVCs, resting ST depression, and ischemia during exercise than patients without EIVA. In a Cox hazards model adjusted for age, cardiovascular disease, exercise‐induced ischemia, ECG abnormalities, exercise capacity and risk factors, EIVA was significantly associated with time to cardiovascular death. The combination of both resting PVCs and EIVA was associated with the highest hazard ratio. Conclusions: EIVA are independent predictors of cardiovascular mortality after adjusting for other clinical and exercise test variables; combination with resting PVCs carries the highest risk.