Open AccessMulticenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT‐CRT): Design and Clinical Protocol
Author(s) -
Moss Arthur J.,
Brown Mary W.,
Cannom David S.,
Daubert James P.,
Estes Mark,
Foster Elyse,
Greenberg Henry M.,
Hall W. Jackson,
Higgins Steven L.,
Klein Helmut,
Pfeffer Mark,
Wilber David,
Zareba Wojciech
Publication year - 2005
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/j.1542-474x.2005.00073.x
Subject(s) - medicine , cardiology , cardiac resynchronization therapy , qrs complex , ischemic cardiomyopathy , heart failure , cardiomyopathy , ejection fraction
The planned MADIT‐CRT trial is designed to determine if CRT‐D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I‐II) and non‐ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF ≤ 0.30), and prolonged intraventricular conduction (QRS duration ≥ 130 ms).