Open AccessThe Brugada Syndrome
Author(s) -
Brugada Pedro,
Brugada Josep,
Brugada Ramon
Publication year - 2000
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/j.1542-474x.2000.tb00251.x
Subject(s) - brugada syndrome , medicine , cardiology , reentry , right bundle branch block , sudden cardiac death , ventricular tachycardia , ajmaline , sodium channel blocker , sodium channel , bundle branch block , implantable cardioverter defibrillator , tachycardia , flecainide , heart disease , ventricular fibrillation , electrocardiography , sodium , atrial fibrillation , chemistry , organic chemistry
The Brugada syndrome is a genetically determined disease caused by mutations of the cardiac sodium channel. The disease affects mainly males in their forties and causes sudden cardiac death because of polymorphic ventricular tachycardia. These patients have a structurally normal heart. The electrocardiogram of this syndrome shows, spontaneously or after Class 1 antiarrhythmic drugs, ST segment elevation in leads V 1 to V 3 and a pattern resembling a right bundle branch block. Phase 2 reentry between epi‐ and endocardiac layers is responsible for the arrhythmias. The only effective treatment at present is implantation of a cardioverter defibrillator. A.N.E. 2000;5(1):88–91