Open AccessComparison of Baroreflex Sensitivity with Age and Indices of Left Ventricular Function in Patients with Dilated Cardiomyopathy
Author(s) -
Menz Volker,
Hoffmann Jürgen,
Grimm Wolfram,
Born Stephan,
Mey Nadja,
Glaveris Christina,
Maisch Bernhard
Publication year - 1999
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/j.1542-474x.1999.tb00367.x
Subject(s) - medicine , cardiology , ejection fraction , dilated cardiomyopathy , cardiomyopathy , baroreflex , diastole , heart failure , prospective cohort study , population , heart rate , blood pressure , environmental health
Background: BRS is an index of autonomic innervation of the heart. Depression of the BRS after Ml is correlated with an increased risk of cardiac mortality and sudden death. However, little is known about the BRS in patients with idiopathic dilated cardiomyopathy (IDC). Methods: In a prospective study the BRS was measured in 89 patients with IDC by the noninvasive phenylephrine method. Mean age of the study population was 48 years, LVEF was 30.2 ± 9.5 %, and left ventricular enddiastolic diameter was 66.9 ± 7.6 mm. Results: BRS did not significantly differ in patients with an LVEF > 30% compared to patients with an ejection fraction 30% (6.2 ± 4.1 vs. 7.3 ± 3.6 ms/mmHg, P > 0.05). There was no difference in the BRS slope between patients with a left ventricula‐ end‐diastolic diameter 65 mm compared to > 65 mm (6.4 ± 3.2 vs. 7.0 ± 4.4 ms/mmHg, P < 0.05) and in patients older than 50 years of age compared to younger patients (6.1 ± 3.7 vs. 7.3 ± 4.0 ms/mmHg, P < 0.05). Conclusion: BRS may be an independent parameter useful for risk stratification in patients with dilated cardiomyopathy. A.N.E. 1999;4(1):67–71