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Assessing Vaccine Effects in Repeated Low‐Dose Challenge Experiments
Author(s) -
Hudgens Michael G.,
Gilbert Peter B.
Publication year - 2009
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.1541-0420.2009.01189.x
Subject(s) - medicine , hiv vaccine , human immunodeficiency virus (hiv) , pandemic , virology , immunology , aids vaccines , transmission (telecommunications) , covid-19 , vaccine trial , computer science , disease , infectious disease (medical specialty) , telecommunications
Summary Evaluation of HIV vaccine candidates in nonhuman primates (NHPs) is a critical step toward developing a successful vaccine to control the HIV pandemic. Historically, HIV vaccine regimens have been tested in NHPs by administering a single high dose of the challenge virus. More recently, evaluation of candidate HIV vaccines has entailed repeated low‐dose challenges, which more closely mimic typical exposure in natural transmission settings. In this article, we consider evaluation of the type and magnitude of vaccine efficacy from such experiments. Based on the principal stratification framework, we also address evaluation of potential immunological surrogate endpoints for infection.