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Conditioning in 2 × 2 Tables
Author(s) -
Proschan Michael A.,
Nason Martha
Publication year - 2009
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.1541-0420.2008.01053.x
Subject(s) - biostatistics , computer science , data science , binary data , binary number , statistics , medicine , mathematics , epidemiology , arithmetic , pathology
Summary Two‐by‐two tables arise in a number of diverse settings in biomedical research, including analysis of data from a clinical trial with a binary outcome and gating methods in flow cytometry to separate antigen‐specific immune responses from general immune responses. These applications offer interesting challenges concerning what we should really be conditioning on—the total number of events, the number of events in the control condition, etc. We give several biostatistics examples to illustrate the complexities of analyzing what appear to be simple data.