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Robust Tests for Treatment Effects Based on Censored Recurrent Event Data Observed over Multiple Periods
Author(s) -
Cook Richard J.,
Wei Wei,
Yi Grace Y.
Publication year - 2005
Publication title -
biometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.298
H-Index - 130
eISSN - 1541-0420
pISSN - 0006-341X
DOI - 10.1111/j.1541-0420.2005.00357.x
Subject(s) - statistics , marginal model , econometrics , random effects model , robustness (evolution) , poisson regression , poisson distribution , crossover , mathematics , computer science , regression analysis , medicine , artificial intelligence , meta analysis , gene , population , biochemistry , chemistry , environmental health
Summary We derive semiparametric methods for estimating and testing treatment effects when censored recurrent event data are available over multiple periods. These methods are based on estimating functions motivated by a working “mixed‐Poisson” assumption under which conditioning can eliminate subject‐specific random effects. Robust pseudoscore test statistics are obtained via “sandwich” variance estimation. The relative efficiency of conditional versus marginal analyses is assessed analytically under a mixed time‐homogeneous Poisson model. The robustness and empirical power of the semiparametric approach are assessed through simulation. Adaptations to handle recurrent events arising in crossover trials are described and these methods are applied to data from a two‐period crossover trial of patients with bronchial asthma.