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Role of Kappa Opioid Receptor in Cardioprotection of Preconditioning: Implications in Cardiac Surgery
Author(s) -
Wong Tak Ming,
Wu Song
Publication year - 2001
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.2001.tb01178.x
Subject(s) - cardioprotection , medicine , ischemic preconditioning , opioid receptor , mitochondrion , pharmacology , receptor , opioid , microbiology and biotechnology , ischemia , biology
A bstract Kappa‐opioid receptor mediates both immediate and delayed cardioprotection of ischemic/metabolic inhibition preconditioning. Both PKC and mitochondria ATP‐sensitive K + channel, mediate the protective action of kappa‐opioid receptor stimulation. In delayed cardioprotection, PKC‐epsilon may produce its effect via mitochondria ATP‐sensitive K + channel, and a stress inducible heat stress protein 70 may also be involved. Metabolic inhibition causes cell death which is accompanied by Ca 2+ overload and mobilization of Ca 2+ from sarcoplasmic reticulum to cytoplasm. The altered Ca 2+ homeostasis is restored partially by kappa‐opioid receptor or metabolic inhibition preconditioning. The finding indicates that opioids such as morphine may be used in the treatment of ischemic heart diseases and in open heart surgery.