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Symposium VI: Calcium Homeostasis in Cardiac Myocytes: β‐Adrenergic Stimulation Modulation of Heart Rate via Synchronization of Ryanodine Receptor Ca2+ Release
Author(s) -
Lakatta Edward G.,
Vinogradova Tatiana M.,
Bogdanov Konstantin Y.
Publication year - 2001
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.2001.tb01177.x
Subject(s) - ryanodine receptor , stimulation , heart rate , adrenergic receptor , ryanodine receptor 2 , calcium , medicine , myocyte , receptor , endocrinology , microbiology and biotechnology , biology , blood pressure
A bstract A robust “fight or flight response”, largely mediated via acute β‐adrenergic receptor (β‐AR) stimulation to the heart to increase its beating rate and contractile performance, is an essential component of the vertebrate survival instinct. While it has long been recognized that activation of β‐AR increases the spontaneous beating rate of sinoatrial nodal cells (SANC), specific links between stimulation of β‐ARs and the resultant increase in firing rate have not been evaluated. Our recent studies 1–2 employed imaging of subcellular Ca 2+ release coupled with recording of membrane potential or current in single, isolated cardiac SANC, to seek novel links between β‐AR stimulation and ryanodine receptor Ca 2+ release and heart rate. An overview of these recent results, which provides novel insights into mechanisms of cardiac reserve that underlie the “fight or flight instinct, is presented here.