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A Mechanosensitive Cation Channel in Endothelial Cells
Author(s) -
Yao Xiaoqiang,
Kwan H.Y.,
Huang Yu
Publication year - 2001
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.2001.tb01154.x
Subject(s) - mechanosensitive channels , medicine , ion channel , channel (broadcasting) , microbiology and biotechnology , biophysics , anatomy , computer network , receptor , biology , computer science
A bstract A mechanosensitive Ca 2+ ‐permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G‐dependent pathway. Inhibition of the channel by cGMP abolishes the Ca 2+ influx elicited by flow. Several inhibitors of the cation channel including Gd 3+ , Ni 2+ , and SK&F‐96365 also inhibit the Ca 2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow‐induced Ca 2+ entry in vascular endothelial cells.