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Oxidative Stress, Nitric Oxide, and Vascular Disease
Author(s) -
Jeremy Jamie Y.,
Yim Anthony P.,
Wan Song,
Angelini Gianni D.
Publication year - 2001
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.2001.tb01151.x
Subject(s) - medicine , peroxynitrite , oxidative stress , nitric oxide , hyperhomocysteinemia , antioxidant , diabetes mellitus , restenosis , nitrotyrosine , coronary artery disease , pharmacology , risk factor , cardiology , nitric oxide synthase , superoxide , endocrinology , biochemistry , enzyme , chemistry , stent
A bstract Superoxide (O 2 − ) is a key risk factor for cardiovascular disease (CVD), including atherogenesis, reperfusion injury, angina, restenosis following balloon angioplasty, and vein graft failure. Axiomatically, O 2 − reacts with nitric oxide (NO) to form peroxynitrite (ONOO) resulting in a depletion of endogenous vascular NO, which is now firmly associated with CVD. Furthermore, risk factors for CVD, in particular diabetes mellitus (DM), dyslipidemia, and hyperhomocysteinemia are all associated with oxidative stress OS. Antioxidant therapies, including the gene transfer of antioxidant enzymes, are potentially valuable in the treatment of CVD.