Premium
Renin, Angiotensin II, and the Development of Effusions Following Bidirectional Glenn and Fontan Procedures
Author(s) -
Mainwaring Richard D.,
Lamberti John J.,
Carter Thomas L.,
Moore John W.,
Nelson Jerald C.
Publication year - 1995
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1995.tb01228.x
Subject(s) - medicine , renin–angiotensin system , radioimmunoassay , angiotensin ii , aldosterone , hormone , plasma renin activity , antidiuretic , endocrinology , urology , cardiology , blood pressure
Pleural effusions are a troublesome complication following bidirectional Glenn and Fontan procedures. It was our hypothesis that effusions may be related to alterations in hormones that regulate fluid homeostasis. We made serial determinations (by radioimmunoassay) of antidiuretic hormone, cortisol, aldosterone, angiotensin II, and renin in patients undergoing bidirectional Glenn (n = 16) and Fontan procedures (n = 24). There were six patients who developed effusions following surgery. These patients had a different endocrinological pattern characterized by persistent elevation in renin (28 ± 9 vs 9 ± 5 ng/mL per hour, p < 0.01) and angiotensin II (110 ± 33 vs 33 ± 14 ng/L, p < 0.01) on the fifth postoperative day as compared to patients who did not develop effusions. These data demonstrate that patients who develop effusions following bidirectional Glenn and Fontan procedures have activation of their renin‐angiotensin system.