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The Role of ATP Sensitive Potassium Channels in Myocardial Protection
Author(s) -
Cason Brian A.,
Gordon Helen J.,
Avery Edwin G.,
Mickey Robert F.
Publication year - 1995
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1995.tb00675.x
Subject(s) - medicine , potassium channel , potassium , cardiology , biophysics , chemistry , organic chemistry , biology
A bstract Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A 1 ‐receptor agonists. A portion of the physiological action of adenosine is, however attributable to adenosine actions on K atp channels. The adenosine A 1 receptor is reported to be linked to the K atp channel in rat ventricular myocytes by a G‐protein mechanism. This article will review the current status of work regarding the role of K atp channels in myocardial preconditioning and will highlight recent work addressing the role of anesthetic effects in these studies. Recent reports and work from our laboratory reveal that several commonly used anesthetic drugs either have direct effects on K atp channels (barbiturates) or have prominent physiological effects that are modulated in large part by K atp channels (volatile anesthetics halothane and isoflurane).