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Anticoagulation and Hemostasis in Cardiac Surgical Patients
Author(s) -
Kondo Nicholas I.,
Maddi Rosemarie,
Ewenstein Bruce M.,
Goldhaber Samuel Z.
Publication year - 1994
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1994.tb00875.x
Subject(s) - medicine , hemostasis , cardiopulmonary bypass , atrial fibrillation , cardiac surgery , aprotinin , heparin , context (archaeology) , warfarin , intensive care medicine , cardiology , anesthesia , paleontology , biology
A bstract Optimizing anticoagulation and hemostasis during cardiopulmonary bypass and perioperatively helps to ensure the best possible clinical outcome. This article reviews the pharmacology of unfractionated and low‐molecular weight heparin, aprotinin, desmopressin, dextran, antiplatelet agents, warfarin, and direct thrombin inhibitors. Their use is discussed in the context of coronary artery surgery, valvular surgery, and mechanical cardiac support devices, as well as in the management of acute ischemic syndromes, atrial fibrillation, and prevention and treatment of venous thromboembolism. Progress in the development and utilization of these anticoagulants and antiplatelet agents has supported the major advances that have been achieved in cardiac surgery.