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Effects of Triiodothyronine on Stunned Myocardium
Author(s) -
Wechsler Andrew S.,
Kadletz Margit,
Ding Mai,
AbdElfattah Anwar,
Dyke Cornelius
Publication year - 1993
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1993.tb01336.x
Subject(s) - medicine , contractility , inotrope , myocardial stunning , stunning , cardiology , ischemia , placebo , perfusion , triiodothyronine , anesthesia , cardiac output , cardiopulmonary bypass , stroke volume , blood pressure , heart rate , hormone , alternative medicine , pathology
A bstract Administration of thyroid hormone, triiodothyronine (T 3 ), causes numerous cardiovascular effects such as increases in stroke volume, cardiac output, heart rate, and myocardial contractility, and decreases in systemic vascular resistance. Along with other stressors, cardiopulmonary bypass (CPB) has been associated with reduced levels of T 3 . We examined the effects of T 3 on early postischemic myocardial recovery in rabbit hearts subjected to crystalloid perfusion to simulate a low T 3 state, and in pig hearts following global ischemia due to CPB. Studies using the former system showed that T 3 administration results in significantly improved developed pressure after reperfusion of mildly ischemic hearts compared to controls, without producing inotropic effects. In more severely stunned rabbit hearts, physiologic and 10 times physiologic doses of T 3 produced significantly improved (p < 0.05) stroke work end‐diastolic length compared to placebo treatment. T 3 treated pigs undergoing CPB and subjected to 30 minutes of global normothermic ischemia experienced significantly enhanced recovery of left ventricular contractility compared to controls at 90 and 120 minutes post reperfusion. Neither placebo nor T 3 affected myocardial adenosine triphosphate levels. These data show that T 3 enhances recovery from myocardial stunning without producing acute inotropic effects.