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The Pathology of Hancock Standard Porcine Valve Prosthesis: A 20‐Year Span of Experience
Author(s) -
VALENTE MARIALUISA,
MINARINI MARCO,
THIENE GAETANO,
BORTOLOTTI UBERTO,
MILANO ALDO,
TALENTI ENRICO,
GALLUCCI VINCENZO
Publication year - 1990
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1990.tb00763.x
Subject(s) - medicine , prosthesis , span (engineering) , life span , pathology , surgery , gerontology , structural engineering , engineering
A bstract A spectrum of events leading to tissue failure is responsible for late dysfunction of Hancock porcine valve xenografts: (a) Primary failure: dystrophic calcification, thrombosis, fibrous tissue overgrowth, primary tears, cuspal hematomas, and stent postbending. (b) Secondary failure: endocarditis and paravalvular leak. Dystrophic calcification is the main factor influencing long‐term durability and accounts in our experience for 88% of primary failure, through different clinical presentations; particularly, incompetence by cusp tearing and egg‐shell fragmentation is by far the most frequent mode of failure. Cusp degeneration by primary tears (in the absence of dystrophic calcification) is an uncommon event, due to lipid infiltration or to right coronary muscle shelf spontaneous or immuno‐related disruption.