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Cardiomyoplasty Benefits in Experimental Myocardial Dysfunction
Author(s) -
MOREIRA LUIZ FELIPE P.,
CHAGAS ANTONIO CARLOS P.,
CAMARANO GUSTAVO P.,
LEIRNER ADOLFO,
PÈOFERNANDES PAULO M.,
LUZ PROTASIO LEMOS,
STOLF NOEDIR A.G.,
JATENE ADIB D.
Publication year - 1989
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1111/j.1540-8191.1989.tb00273.x
Subject(s) - medicine , cardiomyoplasty , cardiology , ventricle , contractility , heart failure , ejection fraction , cardiomyopathy , dilated cardiomyopathy , diastole , hemodynamics , cardiac output , stroke volume , blood pressure
A bstract Beneficial effects of cardiomyoplasty have been documented and the use of this technique in the treatment of dilated cardiomyopathy have been suggested. This study was undertaken to evaluate the effectiveness of stimulated preconditioned latissimus dorsl muscle flaps wrapped around the heart in order to restore ventricular contractility in six adult mongrel dogs with induced myocardial dysfunction by administration of beta blockers and volume loading. Hemodynamic and two‐dimensional echocardiographic evaluation were performed 1 week after the surgical procedure and immediately after heart failure induction. With synchronous pulse train electrical stimulation, cardiac output increased from 1.46 ± 0.13 (± SD) to 2.01 ± 0.16 L/min (p < 0.01), pulmonary wedge pressure decreased from 15.5 ± 1.2 to 11.3 ± 1.6 mmHg (p < 0.01) and left ventricular end‐diastolic pressure from 18.3 ± 2.4 to 13.5 ± 1.4 mmHg (p < 0.04). Echo derived left ventricular ejection fraction increased from 39.3 ± 2.4 to 59.6 ± 2.9% (p < 0.01) and segmental wall shortening from 15.4 ± 1.2 to 26.3 ± 1.7% (p < 0.01), inclusive when the muscle flap was wrapped only around the left ventricle. In conclusion, this study suggests that cardio‐myoplasty may be an alternative method of treatment for irreversible cardiomyopathy, including in patients with a great cardiac enlargement in which muscle flap may only be wrapped partially around the heart.