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Trastuzumab‐Induced Cardiotoxicity: The Role of Two‐Dimensional Myocardial Strain Imaging in Diagnosis and Management
Author(s) -
Stoodley Paul,
Tanous David,
Richards David,
Meikle Steve,
Clarke Jillian,
Hui Rina,
Thomas Liza
Publication year - 2012
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2011.01645.x
Subject(s) - trastuzumab , ejection fraction , cardiotoxicity , cardiology , medicine , strain (injury) , heart failure , breast cancer , cancer , chemotherapy
A 45‐year‐old female breast cancer patient developed heart failure during adjuvant trastuzumab therapy. Her initial left ventricular ejection fraction (LVEF) was 39% and corresponding global longitudinal and circumferential systolic strain measurements were also significantly reduced. Trastuzumab was ceased and supportive cardiac therapy commenced. The ensuing LVEF and systolic strain measurements showed consistent improvement so that trastuzumab was recommenced (while supportive cardiac therapy continued). At this point, reduced circumferential systolic strain with preserved LVEF was observed. Subsequent echocardiograms revealed further reductions in circumferential and longitudinal systolic strain without reductions in LVEF. (Echocardiography 2012;29:E137‐E140)