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Myocardial Longitudinal Peak Systolic Acceleration (pSac): Relationship to Ejection Phase, Pressure, and Contractility
Author(s) -
Odland Hans Henrik,
Brun Henrik,
Sejersted Yngve,
Dalen Marit,
Edvardsen Thor,
Saugstad Ola Didrik,
Thaulow Erik
Publication year - 2012
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2011.01628.x
Subject(s) - preload , contractility , medicine , cardiology , afterload , diastole , isovolumetric contraction , systole , inotrope , ejection fraction , contraction (grammar) , blood pressure , hemodynamics , heart failure
Acceleration has been measured both noninvasively and invasively, during both isovolumic contraction and early ejection and has been shown to reflect contractility, especially through correlation with dP/dt max . In this study timing and amplitude of mitral valve annulus acceleration assessed by tissue Doppler were measured and related to diastolic and systolic events. Invasive load independent measures of contractility, based on pressure–volume relationships, were derived, and pacing was done to modulate and control heart rate. Peak systolic acceleration (pSac) of the mitral valve annulus was shown to occur slightly later but timely related to dP/dt max (P < 0.05), while peak preejection acceleration (pPac) was related to diastolic events. During inotropy and preload modulation dP/dt max was found to be the strongest determinant of pSac (β= 0.9 ± 0.1; P < 0.001 and β= 1.3 ± 0.4; P < 0.001, respectively, log‐transformed variables). PSac increased with pacing at a higher rate (β= 0.1 ± 0.0 cm/sec 2 , P = 0.03). Furthermore, pSac indexed to end‐diastolic volume (EDV) was linearly correlated to load independent contractility parameters (E max , R = 0.7; ESPVR, R = 0.7; and PRSW, R = 0.5), and proved stable toward changes in preload and afterload. The relation between dP/dt max /EDV and pSac/EDV was stable throughout the study. In conclusion we found that peak systolic longitudinal acceleration (pSac) of the mitral valve annulus during aortic valve opening is strongly associated with dP/dt max . Indexed to EDV, pSac may represent a load independent noninvasive contractility parameter. We consider pSac a candidate marker of long‐axis contractility which should be viewed upon as the long‐axis contribution to dP/dt max . (Echocardiography 2012;29:541‐553)