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Analysis of Doppler Flow Spectra of the Superior Vena Cava in a Canine Model of Acute Thromboembolic Pulmonary Hypertension
Author(s) -
Sun Dan Dan,
Chen Hong Mao,
Duan Yun You,
Yuan Li Jun,
Shang Fu Jun,
Liang Ning Nan,
Cao Wei
Publication year - 2011
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2011.01500.x
Subject(s) - medicine , cardiology , pulmonary hypertension , thrombus , doppler echocardiography , doppler effect , pulmonary vein , diastole , inferior vena cava , pulmonary embolism , superior vena cava , femoral vein , blood pressure , atrial fibrillation , physics , astronomy
We aimed to establish a canine model of acute thromboembolic pulmonary hypertension (ATEPH) and to explore the feasibility of diagnosing pulmonary hypertension (PH) through the Doppler flow spectra of the superior vena cava (SVC). A canine model of ATEPH was developed by infusing thrombus into the right femoral vein. The pulmonary arterial pressure was simultaneously measured via a right heart catheter with the guidance of ultrasound. The maximum systolic peak flow velocity (SPV), ventricular reverse peak flow velocity (VRPV), diastolic peak flow velocity (DPV), and atrial reverse peak flow velocity (ARPV) of the SVC were measured by transthoracic echocardiography. ATEPH was successfully established in 24 dogs (88.9%) with the pulmonary arterial systolic pressure (PASP) greater than 30 mmHg. ARPV increased significantly with the increase of PASP, and was positively correlated with PASP (P < 0.001). The ARPV/SPV larger than 0.8 could be better adopted to identify all the subjects with PH in this study. The Doppler flow spectra of the SVC could be employed to assess the severity of ATEPH. (Echocardiography 2011;28:941‐947)