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Dynamic Changes in Microcirculatory Blood Flow during Dobutamine Stress Assessed by Quantitative Myocardial Contrast Echocardiography
Author(s) -
Mathias Jr Wilson,
Kowatsch Ingrid,
Saroute Ally Nader,
Osório Altamiro Filho Ferraz,
Sbano João César Nunes,
Dourado Paulo Magno Martins,
Ramires José Antonio Franchini,
Tsutsui Jeane Mike
Publication year - 2011
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2011.01473.x
Subject(s) - cardiology , medicine , blood flow , dobutamine , contrast (vision) , stress echocardiography , hemodynamics , coronary artery disease , computer science , artificial intelligence
Background: Although dobutamine‐atropine stress echocardiography (DASE) has been widely used for evaluating patients with coronary artery disease (CAD), dynamic changes that occur at microcirculatory level during each stage of stress have not been demonstrated in humans. Aim: We sought to determine variations in myocardial blood flow (MBF) during DASE using quantitative real time myocardial contrast echocardiography (RTMCE). Methods: We studied 45 patients who underwent coronary angiography and RTMCE. Replenishment velocity of microbubbles in the myocardium (β) and MBF reserves were obtained at baseline, intermediate stage (70% of maximal predicted heart rate), peak stress, and recovery phase. Results: β and MBF reserves were lower in patients with than without CAD at intermediate (1.65 vs. 2.10; P = 0.001 and 2.44 vs. 3.23; P = 0.004) and peak (1.63 vs. 3.00; P < 0.001 and 2.14 vs. 3.98; P < 0.001, respectively). In patients without CAD, β, and MBF reserves increased from intermediate to peak and decreased at recovery, while in those without CAD reserves did not change significantly. Optimal cutoff values of β reserve at intermediate, peak, and recovery were 1.78, 2.09, and 1.70, with areas under the curves of 0.80 (95%CI = 0.67–0.94), 0.89 (95%CI = 0.79–0.99), and 0.69 (95%CI = 0.53–0.85). Sensitivity, specificity and accuracy for detecting CAD at intermediate stage were 68% (95%CI = 48–89), 85% (95%CI = 71–98), and 78% (95%CI = 66–90), at peak stress were 79% (95%CI = 61–97), 96% (95%CI = 89–100), and 89% (95%CI = 80–98), and at recovery were 74% (95%CI = 54–93), 65% (95%CI = 47–84), and 69% (95%CI = 55–82), respectively. Conclusion: RTMCE allows for quantification of dynamic changes in microcirculatory blood flow at each stage of DASE. The best parameter for detecting CAD in all stages was β reserve. (Echocardiography 2011;28:993‐1001)