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Assessment of Carotid Compliance Using Real Time Vascular Ultrasound Image Analysis in Marfan Syndrome
Author(s) -
Kiotsekoglou Anatoli,
Moggridge James C.,
Kapetanakis Venedictos,
Newey Valentine R.,
Kourliouros Antonios,
Mullen Michael J.,
Kaski Juan C.,
Nassiri Dariush K.,
Camm John,
Sutherland George R.,
Child Anne H.
Publication year - 2009
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2008.00813.x
Subject(s) - medicine , marfan syndrome , right common carotid artery , cardiology , common carotid artery , ultrasound , compliance (psychology) , intima media thickness , carotid arteries , fibrillin , radiology , psychology , social psychology
Background: Fibrillin‐1 deficiency, dysregulated cytokine transforming growth factor‐β, and increased collagen deposition related to fibrillin‐1 gene mutations could predispose to impaired carotid compliance (CC) in Marfan syndrome (MFS). We sought to detect any alterations in CC using the vascular image analysis system (VIA). Methods and Results: Thirty‐two MFS patients, 20 men and 12 women (mean age 34.2 ± 12.05 years), and 29 controls matched for age, sex, and body surface area (BSA) were recruited. The entire length of each carotid system was initially scanned longitudinally using a 14 MHz linear transducer. Then, a stereotactic clamp held the transducer in contact with the carotid artery. Arterial diameter changes during the cardiac cycle were recorded for 1 minute from both right (RCCA) and left common carotid arteries (LCCA) separately using the VIA system. RCCA and LCCA compliance and distensibility measurements were significantly reduced in MFS patients when compared to controls, P < 0.05. RCCA and LCCA intima‐media thickness did not differ between patients and controls, P > 0.05. MFS diagnosis and age were associated with reduced CC in both carotid arteries after adjusting for variables such as, sex, BSA, heart rate, beta‐blockade, intima‐media thickness, and aortic root size. Conclusions: Our findings showed a reduction in CC in adult patients with MFS. This could be attributed to fibrillin‐1 deficiency resulting in structural abnormalities in the carotid arterial wall.