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Prevalence, Clinical Correlates, and Prognosis of Discrete Upper Septal Thickening on Echocardiography: The Framingham Heart Study
Author(s) -
Diaz Tulio,
Pencina Michael J.,
Benjamin Emelia J.,
Aragam Jayashri,
Fuller Deborah L.,
Pencina Karol M.,
Levy Daniel,
Vasan Ramachandran S.
Publication year - 2009
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2008.00806.x
Subject(s) - medicine , cardiology , odds ratio , framingham risk score , framingham heart study , confidence interval , blood pressure , interventricular septum , disease , ventricle
The upper interventricular septum may be prominent in elderly individuals, a finding referred to as discrete upper septal thickening (DUST). We examined the prevalence, clinical and echocardiographic correlates, and prognostic significance of DUST in a community‐based sample. We evaluated Framingham Study participants who underwent routine echocardiography. In 3562 Framingham Study participants (mean age 58 years, 57% women), DUST was observed in 52 participants. The clinical correlates of DUST were increasing age (odds ratio [OR] per 10 year increment 2.59, 95% confidence intervals [CI] 1.64–4.08) and systolic blood pressure (OR per SD increment 1.55, 95% CI 1.15–2.09). DUST was positively associated with left ventricular (LV) fractional shortening and mitral annular calcification but inversely with LV diastolic dimensions (P < 0.02 for all). On follow‐up (mean 15 years), 732 individuals died (33 with DUST) and 560 experienced a cardiovascular disease (CVD) event (18 with DUST). Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow‐up component of our study suggests that DUST is not independently associated with adverse prognosis.