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Assessment of Left Ventricular Wall Motion in Diabetic Rats Using Velocity Vector Imaging Combined with Stress Echocardiography
Author(s) -
Wei Zhangrui,
Su Haili,
Zhang Haibin,
Zhou Xiaodong,
Zhu Ting,
Liu Liwen,
Zhu Yongsheng,
He Guangbin,
Tian Qiong,
Zhang Jun
Publication year - 2008
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2008.00672.x
Subject(s) - dipyridamole , ventricle , velocity vector , medicine , cardiology , diastole , diabetes mellitus , radial stress , stress echocardiography , blood pressure , endocrinology , coronary artery disease , physics , mechanics
Objective: The aim of this study was to investigate whether velocity vector imaging (VVI) combined with stress echocardiography could detect potential diffused myocardial impairment of the left ventricle (LV) in diabetic rats. Methods: Thirty‐five male SD rats were randomly divided into either the control group or the diabetes mellitus (DM) group (induced with STZ). VVI was performed both at rest and after dipyridamole stress in all rats 12 weeks later. Segmental peak systolic velocity (V s ), diastolic velocity (V d ), radial strain (ɛ r ), circumferential strain (ɛ c ), systolic and diastolic radial strain rate (SR r ), and circumferential strain rate (SR c ) were measured from six segments at the mid‐level of the LV. Results: At rest, systolic and diastolic SR c in the DM group were significantly lower than those in the control group. After dipyridamole stress, all VVI parameters in the DM group were significantly lower than those in the control group, although all values increased significantly after dipyridamole stress compared to those at rest in both groups. Conclusions: The VVI‐derived V s, V d , ɛ r , ɛ c , systolic and diastolic SR r and SR c , combined with dipyridamole stress are all effective parameters in evaluating potential myocardial impairment due to ultrastructural alterations of cardiocytes and microcirculation disturbances in DM rats. Systolic and diastolic SR c may be more sensitive indices that could be useful in detecting myocardial impairment at rest.