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An Echocardiographic Left Ventricular Wall Area Index for Functional Detection of Myocardial Injury in Hemodynamically Unloaded Hearts
Author(s) -
Gilman Gregory,
Hansen William H.,
Hagen Mary E.,
Rosales A. Gabriela,
Bailey Kent R.,
McGregor Christopher G. A.,
Belohlavek Marek
Publication year - 2006
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.2005.00161.x
Subject(s) - ventricle , cardiology , medicine , troponin complex , troponin i , myocardial infarction
Functional assessment of the left ventricle is affected by loading conditions. Detection of rejection‐mediated myocardial injury in a heterotopic heart transplant model is a challenge for the echocardiographer because the heart is in an unloaded state. We examined the relationship of a novel left ventricular (LV) wall area index (LVWAI) and serum cardiac troponin T (cTnT) levels. The LVWAI, based on prior methods of determining LV mass, was defined as the difference between epicardial and endocardial areas divided by the epicardial area. The biphasic morphometric response of LVWAI reflected changes in the cTnT levels and allowed echocardiographic detection of myocardial injury in hemodynamically unloaded hearts.