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Transesophageal Echocardiography with Pathological Correlation in Severe Valvular Disease Associated with Fenfluramine‐Phentermine
Author(s) -
MANGION JUDY R.,
HABBOUB AHMAD A.,
KAMAT BRINDA R.,
TAM STANLEY K. C.
Publication year - 1999
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/j.1540-8175.1999.tb00781.x
Subject(s) - phentermine , medicine , pathological , cardiology , valvular heart disease , fenfluramine , disease , heart disease , radiology , weight loss , obesity , receptor , serotonin
We describe the case of severe diffuse multivalvular disease associated with fenfluramine‐phentermine (Fen‐Phen) in a 52‐year‐old patient who presented to the echocardiography laboratory for evaluation of a new heart murmur and ultimately required isolated aortic valve replacement. The patient was known to have a transthoracic echocardiogram 1 year before starting the diet pill combination that showed no significant valvular disease. Pathological evaluation of the excised aortic valve was consistent with that described with Fen‐Phen use. Transesophageal echocardiography played an important role in defining unique features associated with the valvular disease and in intraoperative management of the patient.