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Circadian and Seasonal Variations of Ventricular Tachyarrhythmias in Patients with Early Repolarization Syndrome and Brugada Syndrome: Analysis of Patients with Implantable Cardioverter Defibrillator
Author(s) -
KIM SUNGHWAN,
NAM GIBYOUNG,
BAEK SEUNGHEE,
OH CHOI HYUNG,
HUN KIM KI,
CHOI KEEJOON,
JOUNG BOYOUNG,
PAK HUINAM,
LEE MOONHYOUNG,
SOON KIM SUNG,
PARK SEUNGJUNG,
KEUN ON YOUNG,
SOO KIM JUNE,
OH ILYOUNG,
CHOI EUEKEUN,
OH SEIL,
CHOI YUNSHIK,
IL CHOI JONG,
WEON PARK SANG,
KIM YOUNGHOON,
YOUNG LEE MAN,
EUY LIM HONG,
LEE YOUNGSOO,
CHO YONGKEUN,
KIM JUN,
LEE DONGIL,
KYOUNG CHO DAE,
KIM YOUHO
Publication year - 2012
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.2011.02287.x
Subject(s) - brugada syndrome , medicine , implantable cardioverter defibrillator , cardiology , circadian rhythm , ventricular fibrillation , repolarization , morning , electrophysiology
Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian and seasonal patterns of ventricular tachyarrhythmia (VTA) in patients with early repolarization syndrome (ERS) have not been determined. We compared the timing of VTAs in patients with ERS and Brugada syndrome (BS). Methods and Results: We enrolled patients with ERS (n = 14) and BS (n = 53) who underwent implantable cardioverter defibrillator (ICD) implantation. The timing of VTAs, including cardiac arrest and appropriate shocks, was determined. During follow up of 6.4 ± 3.6 years in the ERS group and 5.0 ± 3.3 years in the BS group, 5 of 14 (36%) ERS and 10 of 53 (19%) BS patients experienced appropriate shocks (P = 0.37). Cardiac arrest showed a trend of nocturnal distribution peaking from midnight to early morning (P = 0.14 in ERS, P = 0.16 in BS). Circadian distribution of appropriate shocks showed a significant nocturnal peak in patients with ERS (P < 0.0001) but a trend toward a nocturnal peak in patients with BS (P = 0.08). There were no seasonal differences in cardiac arrest in patients with ERS and BS. However, patients with ERS showed a seasonal peak in appropriate shocks from spring to summer (P < 0.0001). There was no significant seasonal peak in patients with BS. The timing of VTAs ( cardiac arrest plus appropriate shock ) showed significant nocturnal distributions in patients with ERS and BS (P < 0.01, respectively). A significant clustering of VTAs was noted from spring to summer (P < 0.01) in patients with ERS, but not in patients with BS (P = 0.42). Conclusions: Incidence of VTAs showed marked circadian variations with night‐time peaks in patients with ERS and BS. (J Cardiovasc Electrophysiol, Vol. 23, pp. 757‐763, July 2012)