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Pacing‐Induced Electromechanical Ventricular Dyssynchrony Does Not Acutely Influence Right Ventricular Function and Global Hemodynamics in Children with Normal Hearts
Author(s) -
FRIEDBERG MARK K.,
DUBIN ANNE M.,
VAN HARE GEORGE F.,
McDANIEL GEORGE M.,
NIKSCH ALISA,
ROSENTHAL DAVID N.
Publication year - 2009
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.2008.01354.x
Subject(s) - cardiology , medicine , qrs complex , hemodynamics , interventricular septum , doppler imaging , ventricular dyssynchrony , diastole , doppler echocardiography , systole , blood pressure , tissue doppler echocardiography , cardiac function curve , diastolic function , cardiac resynchronization therapy , heart failure , ejection fraction , ventricle
Background:Right ventricular (RV) pacing may be detrimental to ventricular function. However, the acute effects of electromechanical dyssynchrony on RV function are not well characterized in children. We studied acute effects of electromechanical dyssynchrony, induced by RV apical and RV outflow pacing, in children with normal hearts, evaluating electromechanical synchrony, hemodynamic response, and RV function.Methods:Seventeen children (mean ± SD, 12 ± 4 years) with normal cardiac structure/function were paced after accessory pathway ablation, at baseline (AOO), and with AV pacing (DOO) from the RV apex and RV outflow. QRS duration was determined from surface ECG. Intra‐ and interventricular mechanical dyssynchrony and regional ventricular function were determined using tissue Doppler imaging. Global RV systolic and diastolic functions were assessed by RV dP/dT max and RV dP/dT neg using pressure‐tipped transducers. Regional RV function was assessed by tissue Doppler imaging. Cardiac index (CI) and blood pressures were measured.Results:RV apical and outflow pacing induced significant electromechanical dyssynchrony manifested by lengthening of the QRS duration, increased LV intraventricular delay (49 ± 34 ms, 53 ± 43 ms, respectively, P < 0.001), and increased interventricular delay (60 ± 29 ms, 55 ± 37 ms, P < 0.0001) versus AOO pacing. However, there was no change in blood pressure, CI, RV dp/dT max , RV dP/dT neg , or regional tissue Doppler velocities, indicating preserved hemodynamics and preserved global and regional RV systolic and diastolic function.Conclusions:In children with normal cardiac function and structure, pacing‐induced electromechanical dyssynchrony did not acutely affect RV systolic and diastolic function and did not acutely alter global hemodynamics. Therefore, electromechanical dyssynchrony may only be an important therapeutic target in the setting of decreased RV function.