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Mortality Following Defibrillator Implantation in Patients with Renal Insufficiency
Author(s) -
ECKART ROBERT E.,
GULA LORNE J.,
REYNOLDS MATTHEW R.,
SHRY ERIC A.,
MAISEL WILLIAM H.
Publication year - 2006
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.2006.00550.x
Subject(s) - medicine , heart failure , cardiology , coronary artery disease , hemodialysis , cohort , kidney disease , diabetes mellitus , mortality rate , renal replacement therapy , endocrinology
Patients with renal insufficiency have an increased risk of atherosclerotic coronary artery disease, cardiovascular events, and sudden cardiac death. Due to under‐representation of patients with renal disease in large clinical trials, outcomes of implantable cardioverter defibrillator (ICD) implantation in this group remain unclear. Methods and Results: Inpatient and ambulatory records were reviewed for 741 consecutive patients undergoing 947 defibrillator implants or replacements at Department of Defense Medical Facilities. Demographics, medical history, and mortality were reviewed. The mean age of the cohort was 64 ± 14 years and 599 (80.8%) were male. There were 173 patients (23.3%) with chronic renal insufficiency, 22 (3.0%) undergoing hemodialysis, and 546 (73.7%) without reported renal disease. The mean number of annual hospital admissions for heart failure among patients with and without renal failure was 3.8 ± 4.0 versus 1.2 ± 1.9 (P < 0.0001), respectively. The 1‐year survival for those without renal insufficiency was 96.6%, compared to 87.8% for those with chronic renal insufficiency, and 88.7% for those undergoing hemodialysis. Multivariate analysis demonstrated a significant association between mortality among ICD patients and renal insufficiency, independent of coexisting congestive heart failure, ischemic cardiomyopathy, and diabetes mellitus (P < 0.0001). Conclusions: Among ICD recipients, those with renal insufficiency have a significantly higher mortality rate than those without renal insufficiency. Among a cohort of patients with ICDs, those with known renal insufficiency have higher rates of health care resource utilization and more heart failure admissions. Development of a national registry for ICDs should include data with regard to renal function.