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Na + Current in Human Ventricle: Implications for Sodium Loading and Homeostasis
Author(s) -
MAKIELSKI JONATHAN C.,
FARLEY AMANDA L.
Publication year - 2006
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.2006.00380.x
Subject(s) - ventricle , homeostasis , gating , sodium channel , medicine , ion channel , electrophysiology , intracellular , sodium , nav1.5 , biophysics , cardiac function curve , microbiology and biotechnology , heart failure , cardiology , chemistry , biology , receptor , organic chemistry
The Na current (I Na ) in human ventricle is carried through a specific isoform of the voltage gated Na channel in heart. The pore forming α‐subunit is encoded by the gene SCN5A . Up to four β‐subunits may be associated, and the larger macromolecular complex may include attachments to cytoskeleton and scaffolding proteins, all of which may affect the gating kinetics of the current. I Na underlies initiation and propagation of action potentials in the heart and plays a prominent role in cardiac electrophysiology and arrhythmia. In addition, I Na also loads the ventricular cell with Na + ions and plays an important role in intracellular Na homeostasis. This review considers the structure and function of the human cardiac Na channel that carries I Na with a particular consideration of the implications of alterations in I Na in acquired cardiac diseases such as hypertrophy, failure, and ischemia, which affect Na loading.