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Transient Local Changes in Right Ventricular Monophasic Action Potentials Due to Ajmaline in a Patient with Brugada Syndrome
Author(s) -
ECKARDT LARS,
KIRCHHOF PAULUS,
JOHNA ROBERT,
BREITHARDT GÜNTER,
BORGGREFE MARTIN,
HAVERKAMP WILHELM
Publication year - 1999
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1999.tb01272.x
Subject(s) - ajmaline , brugada syndrome , medicine , cardiology , repolarization , palpitations , ventricular outflow tract , electrocardiography , anesthesia , electrophysiology
Monophasic Action Potential Recording in Brugada Syndrome. A 48‐year‐old patient with recurrent episodes of palpitations and syncope presented with transient ST segment elevation in the right precordial ECG leads. Structural heart disease was excluded. No arrhythmias were inducible by programmed ventricular stimulation. Parallel to ST elevation after intravenous ajmaline, a gradual and reversible delay in the upstroke of right ventricular (RV) monophasic action potentials (MAPs) occurred that was most marked in the RV outflow tract and nearly absent at right free‐wall recordings. Ajmaline led to a cycle length‐dependent increase in RV dispersion of repolarization. Thus, right endocardial MAPs may demonstrate regionally different action potential changes that may contribute to the ECG changes in Brugada syndrome.