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Cisapride‐Induced Torsades de Pointes
Author(s) -
VITOLA JOÃO,
VUKANOVIC JASMINKA,
RODEN DAN M.
Publication year - 1998
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1998.tb00888.x
Subject(s) - cisapride , torsades de pointes , medicine , qt interval , drug , concomitant , pharmacology , adverse effect , cardiology
Cisapride‐Induced Torsades de Pointes. Two cases of torsades de pointes associated with cisapride are presented, both in association with concomitant drug therapy that inhibits cisapride biotransformation. In one case, plasma cisapride was elevated days after the event, strongly supporting a role for accumulation of the drug in causing the arrhythmia. It is emphasized that these adverse drug reactions are not idiosyncratic, hut rather are predictable based on an understanding of the underlying mechanisms.