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Early Afterdepolarization Abolished by Potassium Channel Opener in a Patient with Idiopathic Long QT Syndrome
Author(s) -
SATO TETSUYA,
HATA YOSHIKI,
YAMAMOTO MIKA,
MORITA HIROSHI,
MIZUO KOZO,
YAMANARI HIROSHI,
SAITO DAIJI,
OHE TOHRU
Publication year - 1995
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1995.tb00400.x
Subject(s) - nicorandil , afterdepolarization , medicine , cardiology , ventricle , potassium channel opener , anesthesia , long qt syndrome , potassium channel , qt interval , electrophysiology , repolarization
Abolished Early Afterdepolarization by Nicorandil. We describe a 17‐year‐old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased KAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.