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Electrical Proarrhythmia with Procainamide:
Author(s) -
FIKSINSKI EDMUND,
MARTIN DAVID,
VENDITTI FERDINAND
Publication year - 1994
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1994.tb01154.x
Subject(s) - procainamide , proarrhythmia , medicine , disopyramide , mexiletine , cardiology , defibrillation threshold , defibrillation , ventricular tachycardia , implantable cardioverter defibrillator , ventricular fibrillation , amiodarone , tachycardia , anesthesia , atrial fibrillation
ICD‐Drug Proarrhythmia. A 78‐year‐old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy. Electrophysiologic evaluation demonstrated failure to terminate ventricular tachycardia with maximal energy shocks, but consistent termination by low energy discharges. Procainamide had no effect upon the defibrillation threshold. The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.