Premium
CNS Regulation of Cardiac Rhythm and the Potential for Pain‐Induced Arrhythmia
Author(s) -
GILLIS RICHARD A.,
MANDAL ALOKE K.,
GATTI PHILIP J.,
NORMAN WESLEY P.,
QUEST JOHN A.
Publication year - 1991
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1991.tb01361.x
Subject(s) - medicine , area postrema , rhythm , serotonergic , neuroscience , hindbrain , cardiac function curve , cardiac arrhythmia , heart rhythm , cardiology , central nervous system , atrial fibrillation , serotonin , heart failure , receptor , biology
CNS Control of Cardiac Rhythm. The purpose of our studies was to determine brain areas that influence cardiac rhythm. Studies were performed in anesthetized cats and indicate that a yet undetermined site in the hindbrain involving GABAergic mechanisms has a major influence over cardiac rhythm. In addition, a serotonergic mechanism involving 5‐HT 2 receptors in the subretrofacial nucleus is responsible for selective activation of sympathetic neurons to the ventricle of the heart. Our data also indicate that neurons in the area postrema exert a major effect on cardiac rhythm. Finally, the question of whether pain‐induced changes in cardiovascular function involves neurons in the subretrofacial nucleus is also addressed.