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CLASS IA AND CLASS IB ANTIARRHYTHMIC DRUGS — A Review of Their Pharmacokinetics, Electrophysiology, Efficacy, and Toxicity
Author(s) -
SALERNO DAVID M.
Publication year - 1990
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/j.1540-8167.1990.tb01697.x
Subject(s) - medicine , qt interval , refractory period , qrs complex , electrophysiology , prolongation , pharmacology , cardiac electrophysiology , effective refractory period , anti arrhythmia agents , cardiology , atrial fibrillation
Class 1A agents share the electrophysiologic property of slmuing of V max of phase 0 of the action potential and moderate prolongation of the action potential duration and refractoriness. Their electrocardiographic effect in therapeutic doses is to prolong the QT c . interval due to prolongation of the JT c interval. The PR and QRS intervals are not prolonged in therapeutic doses. This group of agents contains the standard antiarrhythmic agents released prior to 1984. The older drugs in this group wilt be reviewed only briefly in this report. Their effect on suppression of ventricular ectopic depolarizations will be reviewed for comparison with the newer agents.