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Sudden Death Late After Doxorubicin Administration: Use of Electrophysiological Study and Treatment by Automatic Implantable Cardioverter Defibrillator
Author(s) -
EPSTEIN ANDREW E.,
MCGIFFIN DAVID C.,
KAY G. NEAL,
PLUMB VANCE J.,
SHEPARD RICHARD B.
Publication year - 1989
Publication title -
journal of electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 0892-1059
DOI - 10.1111/j.1540-8167.1989.tb01566.x
Subject(s) - medicine , implantable cardioverter defibrillator , cardiology , electrophysiology , sudden cardiac death , dilated cardiomyopathy , cardiac electrophysiology , doxorubicin , heart failure , chemotherapy
Two patients who survived cardiac arrest late after doxorubicin administration are described. Both patients had nonischemic, dilated cardiomyopathies and underwent electrophysiological studies during which no ventricular arrhythmias were induced. Their negative electrophysiological studies despite well documented cardiac arrests and subsequent clinical courses suggest that patients with cardiomyopathies after doxorubicin administra tion and dilated cardiomyopathies of other etiologies have similar natural histories. Treatment with an automatic implantable cardioverter defibrillator appears to be a reasonable therapeutic option for patients with anthracyline associated cardiac disease who have survived their malignancy but at the price of developing life‐threatening arrhythmias.