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Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure
Author(s) -
BAKER BONNIE J.,
BRODSKY MICHAEL A.,
DINH HA,
ALLEN BYRON J.,
COTTER BARBARA,
LUCKETT CATHY,
MURPHY MARVIN L.
Publication year - 1987
Publication title -
journal of electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 0892-1059
DOI - 10.1111/j.1540-8167.1987.tb01444.x
Subject(s) - ejection fraction , propafenone , medicine , cardiology , hemodynamics , heart failure , atrial fibrillation
The effects of propafenone on left ventricular function and hemodynamics are presented in this study. In one group of 13 patients who underwent electrophysiological testing and subsequent chronic oral therapy with propafenone, eight had left ventricular ejection fractions determined by nuclear study before and during therapy with the drug. Initial measurements ranged from 22% to 39% (mean 30%), while those on chronic therapy showed no statistical difference and ranged from 22% to 48% (mean 30%). In a separate dose titration study of 14 patients, left ventricular ejection fraction showed a modest but significant decrease (52%± 9% to 48%± 11%; p < 0.05). This change was more marked in patients with an initial low ejection fraction. Propafenone appears to be safe in these patients but should be administered with caution in patients with particularly low ejection fractions.