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Mexiletine in the Prevention of Sudden Cardiac Death: Experimental Evaluation and Clinical Implications
Author(s) -
ZUANETTI GUILIO,
VANOLI EMILIO,
SCHWARTZ PETER J.
Publication year - 1986
Publication title -
clinical progress in electrophysiology and pacing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 8756-9264
DOI - 10.1111/j.1540-8167.1986.tb01739.x
Subject(s) - mexiletine , medicine , lidocaine , propafenone , cardiology , sudden cardiac death , prazosin , myocardial infarction , amiodarone , sudden death , anesthesia , atrial fibrillation , antagonist , receptor
To investigate the anti arrhythmic efficacy of various agents in preventing sudden cardiac death triggered by transient acute myocardial ischemia, we designed two protocols, using adult cats, to induce coronary artery occlusion followed by sympathetic stimulation or reperfusion to produce arrhythmias. Mexiletine, reported in detail here, and other agents were then administered and their effectiveness measured. The experimental findings showed mexiletine to be ineffective; lidocaine and propafenone to be similarly ineffective; amiodarone and calcium channel blockers to be highly effective; and propranoiol and prazosin to be relatively effective. Extrapolating clinical implications from these experimental data may be limited by the facts that anesthesia was used during the surgical procedure, which can modify the cardiovascular responses to ischemia, and that we used animals with normal coronary arteries.