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A Phenotypic Combination of Idiopathic VF and Brugada Syndrome
Author(s) -
MARTINEK MARTIN,
PURERFELLNER HELMUT
Publication year - 2010
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2010.02715.x
Subject(s) - medicine , brugada syndrome , phenotype , cardiology , genetics , gene , biology
This case study shows a young male presenting a mixture of two disease entities: (1) Brugada syndrome with a nearly‐normal baseline electrocardiogram and positive Ajmaline drug challenge as well as (2) idiopathic ventricular fibrillation including extremely short‐coupled monomorphic ventricular premature beats (VPB) triggering ventricular fibrillation (coupling interval 318 ± 21 ms). In this phenotypic patient group—more suggestive of idiopathic ventricular fibrillation due to the ultra‐short coupling interval of the VPBs—drug treatment with a class IA agent such as Quinidine might be an important option to implantable cardioverter‐defibrillator and ablation therapy. (PACE 2010; 33:e84–e87)