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Impact of AV Conduction Disorders on SafeR Mode Performance
Author(s) -
THIBAULT BERNARD,
SIMPSON CHRISTOPHER,
GAGNÉ CARLÉRIC,
BLIER LOUIS,
SENARATNE MANOHARA,
McNICOLL SERGE,
STUGLIN CARLO,
WILLIAMS RANDY,
PINTER ARNOLD,
KHAYKIN YAARIV,
NITZSCHE REMI
Publication year - 2009
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2008.02293.x
Subject(s) - medicine , atrioventricular block , atrial fibrillation , cardiology , population , adverse effect , sick sinus syndrome , environmental health
Purpose: CAN‐SAVE R is a Canadian multicenter study that compares the effects of a new pacing mode algorithm designed to minimize right ventricular (V) pacing versus DDD mode with a long atrioventricular (AV) delay in a general population of pacemaker (PM) recipients .Study Participants: Patients with permanent atrial fibrillation (AF) or high‐degree AV block (AVB) were excluded. We present preliminary data collected in 208 patients (mean age = 71 ± 11 years, 68% men), for the 2‐month baseline period during which all PM were programmed in the new pacing mode. The pacing indications were sinus node disease (SND) without AVB in 39%, AVB without SND in 30%, SND and AVB in 16%, and miscellaneous in 15% of patients.Results: The mean percent V pacing in the overall population was 9.5 ± 23.8% (range = 0–100%, median <1%), ranging between 0.5 ± 1.5% (median = 0) in patients without AVB and 18.7 ± 31.2% in patients (median = 1) with AVB. Adverse events potentially related to the new pacing mode were observed in two patients with AVB.Conclusions: A new pacing mode was effective and safe in a general population of PM recipients without permanent AVB and was associated with an overall <1% median V pacing. CAN‐SAVE R will compare the long‐term effects of the new pacing mode with DDD with a long AV delay on clinical outcomes and cardiac function.