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Sinus Rhythm Restoration after Atrial Fibrillation: The Clinical Value of N‐Terminal Pro‐BNP Measurements
Author(s) -
DANICEK VLADIMIR,
THEODOROVICH NICK,
BARCHAIM SHMUEL,
MILLER ASAF,
VERED ZVI,
KORENMORAG NIRA,
URIEL NIR,
CZURIGA ISTVAN,
SHOPEN ANDREY,
BRANTRISS NURIT,
KALUSKI EDO
Publication year - 2008
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2008.01121.x
Subject(s) - medicine , interquartile range , sinus rhythm , atrial fibrillation , cardiology
Aim: To examine the effects of sinus rhythm (SR) restoration on N‐Terminal pro‐BNP (NTP‐BNP) in patients with atrial fibrillation (AF).Methods: Subjects with paroxysmal and persistent AF and absence of organic heart disease were prospectively studied. Chemical or electrical restoration of SR was attempted within 48 hours (n = 37) or >3 weeks (n = 73). Clinical and laboratory (NTP‐BNP, 72‐hour Holter monitor, and electrocardiogram) assessment were obtained at baseline and at 1, 30, and 180 days after SR restoration. Patients were divided into three predefined “outcome groups”: (a) maintenance of SR for 1 month, (b) SR with recurrent paroxysmal AF (PaAF), and (c) early (<30 days) recurrence persistent AF (RAF).Results: Of the 110 patients enrolled, 89 had initial successful SR restoration. Baseline NTP‐BNP was 936 pg/mL (interquartile range (IQR) 333–2,026); ratio between baseline and 30‐day NTP‐BNP was 10.2 (IQR 6.42–22.0) for SR group, 3.3 (IQR 2.45–7.34) for PaAF, and 1.07 (IQR 0.87–1.22) for RAF (P < 0.001). Patients with ratio ≤3 were more likely to have PaAF (46% vs 3%, OR 30, P < 0.001).Conclusion: With SR restoration, NTP‐BNP decline is observed up to 1 month. NTP‐BNP drop is partially or completely abolished by PaAF and RAF, respectively. NTP‐BNP does not predict successful SR restoration.