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Concomitant‐Acquired Long QT and Brugada Syndromes Associated with Indapamide‐Induced Hypokalemia and Hyponatremia
Author(s) -
MOK NGAISHING,
TONG CHAKKWAN,
YUEN HOCHUEN
Publication year - 2008
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2008.01085.x
Subject(s) - medicine , hypokalemia , brugada syndrome , hyponatremia , indapamide , concomitant , long qt syndrome , cardiology , qt interval , diuretic
Electrolyte disturbances are known to cause acquired Long QT syndrome (LQTS) and Brugada syndrome. While a reduction in INa due to SCN5A mutation is implicated as the underlying mechanism in Brugada syndrome, hyponatremia, which can give rise to a reduced INa, has never been reported in literature as a cause or precipitating factor in this syndrome. We detailed a case in which concomitant‐acquired LQTS and Brugada syndrome were associated with severe hypokalemia and hyponatremia following indapamide use for treatment of hypertension and highlighted the potential role of hyponatremia in the pathogenesis of the acquired form of Brugada syndrome.