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The Safety and Efficacy of Ibutilide in Children and in Patients with Congenital Heart Disease
Author(s) -
HOYER ANDREW W.,
BALAJI SESHADRI
Publication year - 2007
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2007.00799.x
Subject(s) - ibutilide , medicine , atrial flutter , cardioversion , atrial fibrillation , cardiology , heart disease , anesthesia
Background: The safety and efficacy of ibutilide in the cardioversion of atrial flutter and atrial fibrillation in children and in patients with congenital heart disease (CHD) is unknown.Methods: Data from 19 patients (age 6 months to 34 years, median 16 years) who received ibutilide for atrial flutter or atrial fibrillation between 1996 and 2005 was retrospectively reviewed. There were 15 patients with CHD (14 had prior heart surgery); four children had normal heart structure.Results: There were 74 episodes of atrial flutter and four episodes of atrial fibrillation (median episodes per patient was one, range 1–31). Ibutilide converted 55 of all the episodes (71%). Ibutilide was successful during its first‐ever administration in 12 of 19 patients (63%). Fourteen episodes in six patients required electrical cardioversion after ibutilide failed. There were no episodes of symptomatic bradycardia. One patient went into torsade de pointes and one patient had nonsustained ventricular tachycardia.Conclusion: With careful monitoring, ibutilide can be an effective tool in selected patients for cardioversion of atrial flutter.