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Selective Myocardial Isolation and Ventricular Fibrillation
Author(s) -
CHORRO FRANCISCO J.,
BLASCO ESTRELLA,
TRAPERO ISABEL,
CÁNOVES JOAQUÍN,
FERRERO ÁNGEL,
MAINAR LUIS,
SUCHMIQUEL LUIS,
SANCHIS JUAN,
BODÍ VICENTE,
CERDÁ JOSÉ M.,
ALBEROLA ANTONIO,
SUCH LUIS
Publication year - 2007
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2007.00676.x
Subject(s) - medicine , ventricular fibrillation , cardiology , border zone , myocardial infarction
Background: Few experimental studies have analyzed the effects of selective radiofrequency (RF) lesions upon ventricular fibrillation (VF). The RF‐induced isolation of selected zones would make it possible to determine whether these zones are essential for existence of the arrhythmia.Methods: In 31 Langendorff‐perfused rabbit hearts, the characteristics and inducibility of VF were analyzed before and after the induction of RF lesions comprising: (1) the posterior zone of the septum and of the walls of both ventricles (n = 10); (2) the anterior zone of the septum and of the walls of both ventricles (n = 11); and (3) the midseptal zone (n = 10).Results: Complete isolation of the zone encompassed by the lesions was obtained in 5, 6, and 5 experiments of series 1, 2, and 3, respectively. In these experiments, the arrhythmia was only induced from within the zone encompassed by the lesions in one experiment belonging to series 2 (P < 0.05 with respect to baseline). In contrast, in all but one of the cases in series 2, VF could be induced from outside the isolated zone (ns vs baseline). Partial isolation was obtained in five experiments of each series. In these experiments, on pacing from within the partially isolated zone, sustained VF was not induced in any experiment (P < 0.05 with respect to baseline), while in all cases VF could be induced on pacing from the external zone (ns vs baseline).Conclusion: In the experimental model used, the three zones studied were not essential for maintaining VF. In most cases, their partial or total isolation avoided inducibility of the arrhythmia in those zones, though not in the remaining myocardium.