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Altered Autonomic Cardiac Control Predicts Restenosis After Percutaneous Coronary Intervention
Author(s) -
GOERNIG MATTHIAS,
GRAMSCH MATTHIAS,
BAIER VICO,
FIGULLA HANSRAINER,
LEDER UWE,
VOSS ANDREAS
Publication year - 2006
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2006.00315.x
Subject(s) - restenosis , medicine , cardiology , ejection fraction , percutaneous coronary intervention , conventional pci , blood pressure , coronary artery disease , diastole , heart failure , stent , myocardial infarction
Background: Early and late restenosis in up to 30% remains a major problem for long‐term success after percutaneous coronary intervention (PCI). Compared to bare metal stents, the use of drug‐eluting stents reduces restenosis below 10%, but implant coasts have to be considered. In restenosis noninvasive testing lacks diagnostic power. We applied a new approach to identify patients with a high risk for restenosis after PCI by combining heart rate (HR) and blood pressure variability (BPV) analyses.Methods: In 52 patients with clinical suspicion of restenosis and history of PCI, we investigated patterns of cardiovagal autonomic regulation prior to cardiac catheterization. The patients were separated in (i) patients with restenosis (CAD+R) and (ii) patients without restenosis (CAD−R), where restenosis is defined as a stenosis greater than 75% of luminal diameter in at least one main vessel. The following parameters/methods were evaluated: Canadian Cardiovascular Society grade (CCS‐grade), vessel disease score (CAD‐level), left ventricular ejection fraction (LVEF), heart rate variability (HRV), BPV, baroreflex sensitivity (BRS), as well as HR turbulence and blood pressure (BP) potentiation caused by premature ventricular complexes.Results: Whereas age, LVEF, CAD‐level, CCS‐grade, and mean BP did not differ between CAD+R and CAD−R, significant differences were found in (i) BPV: diastolic LF/P, systolic, and diastolic UVLF, (ii) in BRS: slope of tachycardic sequences, and (iii) in extrasystolic parameters: heart rate turbulence onset (HRTO) and potentiation of systolic BP (SBPP). Standard HRV parameters did not show significant differences between the groups. Using the two parameters diastolic LF/P (threshold >0.2) and HRTO (threshold >0) restenosis were predicted in 83.4%.Conclusions: These results demonstrate that indicators of sympathetic activation or vagal depression identify restenosis in patients after PCI, thus opening a perspective for a new noninvasive monitoring.