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Suboptimal Glycemic Control, Independently of QT Interval Duration, Is Associated with Increased Risk of Ventricular Arrhythmias in a High‐Risk Population
Author(s) -
CHENSCARABELLI CAROL,
SCARABELLI TIZIANO M.
Publication year - 2006
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2006.00298.x
Subject(s) - medicine , qt interval , glycemic , cardiology , ventricular tachycardia , sudden cardiac death , diabetes mellitus , implantable cardioverter defibrillator , population , incidence (geometry) , endocrinology , insulin , physics , environmental health , optics
Background: Although cardiovascular disease is the leading cause of mortality in diabetic patients, little is known about the impact of glycemic control on ventricular tachycardia (VT).Objective: To investigate whether hemoglobin A1c (HbA1c) is associated with increased incidence of VT.Methods: A retrospective study of 336 implantable cardioverter‐defibrillator patients (both diabetes mellitus (DM) and non‐DM) was conducted.Results: HbA1c levels between 8% and 10% had a significant association with spontaneous VT, but not with QT/QTc.Conclusions: Glycemic index is a significant predictor of spontaneous VT, independently of QT interval. Optimal glycemic control may help reduce occurrence of VT and sudden cardiac death in high‐risk DM patients.