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QT Interval Prolongation and Torsades de Pointes Due to a Coadministration of Metronidazole and Amiodarone
Author(s) -
KOUNAS STAVROS P.,
LETSAS KONSTANTINOS P.,
SIDERIS ANTONIOS,
EFRAIMIDIS MICHALIS,
KARDARAS FOTIOS
Publication year - 2005
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2005.09348.x
Subject(s) - torsades de pointes , medicine , amiodarone , qt interval , metronidazole , prolongation , long qt syndrome , cardiology , atrial fibrillation , anesthesia , antibiotics , biology , microbiology and biotechnology
This report documents the occurrence of torsades de pointes (TdP) caused by marked QT interval prolongation in the case of a 71‐year‐old woman receiving both metronidazole and amiodarone for the treatment of pseudomembranous colitis and paroxysmal atrial fibrillation. The case highlights a previously unknown drug interaction. The role of inhibition of cytochrome P‐450 CYP3A4 is discussed.