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Coronary Artery Disease Alters Ventricular Repolarization Dynamics in Type 2 Diabetes
Author(s) -
VRTOVEC BOJAN,
SINKOVEC MATJAZ,
STARC VITO,
RADOVANCEVIC BRANISLAV,
SCHLEGEL TODD T.
Publication year - 2005
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2005.00076.x
Subject(s) - medicine , cardiology , coronary artery disease , diabetes mellitus , repolarization , type 2 diabetes , ventricular repolarization , stenosis , endocrinology , electrophysiology
Ventricular repolarization dynamics (VRD) is an important predictor of outcome in diabetes.We examined the potential impact of coronary artery disease (CAD) on VRD in type 2 diabetic patients. We recorded 5‐minute high‐resolution resting electrocardiograms in 38 diabetic patients undergoing elective coronary angiography, and in 38 age‐ and gender‐matched apparently healthy subjects (controls). Using leads‐I and ‐II, time‐domain indices of VRD were calculated. Coronary angiography was regarded as positive if ≥ 50% stenosis was found. Angiography was positive in 21 diabetic patients (55%). Patients with CAD had a significantly higher degree of VRD than controls (SDNN(QT): 15.81 ± 7.22 ms versus 8.94 ± 6.04 ms; P < 0.001, rMSSD(QT): 21.02 ± 7.07 ms versus 11.18 ± 7.45 ms; P < 0.001). Ventricular repolarization dynamics in diabetic patients with negative angiograms did not differ from VRD in controls (SDNN(QT): 8.94 ± 6.04 ms versus 7.44 ± 5.72 ms; P = 0.67, rMSSD(QT): 11.18 ± 7.45 ms versus 10.22 ± 5.35 ms; P = 0.82). CAD increases VRD in patients with type 2 diabetes. Therefore, changes in ventricular repolarization in diabetic patients may be due to silent CAD rather than due to diabetes per se.