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Predictive Value of High‐Sensitivity C‐Reactive Protein in Patients with Idiopathic Dilated Cardiomyopathy
Author(s) -
LAMPARTER STEFFEN,
GRIMM WOLFRAM
Publication year - 2005
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2005.00034.x
Subject(s) - medicine , ejection fraction , cardiology , multivariate analysis , cardiomyopathy , c reactive protein , dilated cardiomyopathy , heart failure , inflammation
We analyzed the serum concentrations of high‐sensitivity C‐reactive protein (hsCRP) at the time of diagnostic cardiac catheterization in 198 patients with idiopathic dilated cardiomyopathy (IDC) to evaluate its prognostic value. Patients were dichotomized according to a median value of hsCRP of 2 mg/dL. Predefined study endpoints over 69 ± 33 months of follow‐up included major arrhythmic events and transplant‐free survival. Major arrhythmic events during follow‐up occurred in 20 of 98 patients (20%) with low, compared to 22 of 100 patients (22%) with high hsCRP (ns). By multivariate analysis, a depressed left ventricular ejection fraction (LVEF) was the only significant predictor of arrhythmic risk. Death or cardiac transplantation was observed in 36% of patients with high, versus 22% of patients with low hsCRP (P < 0.05). By multivariate analysis, hsCRP and LVEF were independent predictors of transplant‐free survival. Thus, in this patient population with IDC, hsCRP had independent prognostic value with regard to transplant‐free survival, but did not contribute in the stratification with regard to arrhythmic risk.